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We performed Killer cell immunoglobulin‐like receptor (KIR) genotyping on 1271 individuals of Chinese Han origin including 102 families and 965 unrelated individuals. The families (with one child and both parents) were subjected for haplotype analysis. Forty‐one different genotypes were identified. The frequencies of the KIR genotypes found in the family panel were confirmed by those found in the...
The aim of this study was to investigate the HLA‐G 14‐bp insertion/deletion (I/D) polymorphism among end‐stage renal disease (ESRD) patients. Cytomegalovirus (CMV) infection, acute allograft rejection (AR) and overall survival after renal transplantation was investigated in 300 ESRD patients and 302 age, sex and ethnicity‐matched controls. Sequencing was performed to evaluate the impact of HLA‐G promoter...
Rheumatoid arthritis (RA) is an inflammatory disease associated with high risk of cardiovascular (CV) events. Recently, the rs964184 polymorphism has been associated with coronary artery disease in nonrheumatic Caucasian individuals. 2160 Spanish RA patients were genotyped for the rs964184 polymorphism. Sex, age at diagnosis and traditional CV risk factors (diabetes mellitus, dyslipidemia and smoking...
Studies of the effect of minor H antigen mismatching on the outcome of renal transplantation are scarce and concern mainly single center studies. The International Histocompatibility and Immunogenetics Workshops (IHIW) provide a collaborative platform to execute crucial large studies. In collaboration with 16 laboratories of the IHIW, the role of 15 autosomal, 10 Y‐chromosome encoded minor H antigens...
T lymphocytes are key players of adaptive immune responses. Upon recognition of specific peptides presented by human leukocyte antigen (HLA) molecules on antigen presenting cells (APC), these cells execute subset‐related functions such as killing, help and regulation. The ontogeny, the activation and the effector functions of T lymphocytes are all steps of T‐lymphocyte life cycle that rely on high...
The aim of the study was to investigate and compare the clinical manifestations between HLA‐B27+ and HLA‐B27− ankylosing spondylitis (AS) patients in order to obtain knowledge of the impact of HLA‐B27 status on AS, and to inform clinical treatment. A nationwide epidemiological investigation was performed from November 2008 to October 2010. The demographic data and clinical characteristics, and the...
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